C3H genetic background do not exhibit anyseizure phenotype. These animals also display a slight alteration in their tailphenotype (e.g., kinked tail) that is believed to be due to the mixed geneticbackground of the strain and is not related to transgene expression. Thisstrain does not carry the retinal degeneration allele Pde6brd1.
In contrast, APP/PS1 hemizygotes on aC57BL/6J-congenic background exhibit seizure activity. Specifically, hemizygousmice on the C57BL/6 background (N9B6) exhibit a high incidence of seizures, asdetected by video-EEG. 25% of transgenic mice, 3 to 3.5 months in age, exhibitat least 1 seizure. By 4.5 months of age, seizure incidence increases to 55%.10-15% mortality is reported for transgenic mice on the congenic (N9) C57BL/6background (Minkeviciene et al. J Neurosci. 2009). At 17-18 weeks ofage, hemizygous mice on the congenic C57BL/6J background (N13) exhibitepileptiform discharges as detected by video-EEG. Mortality was 38% (6/16) andsome mutant mice experienced spontaneous seizures during the experiments.Antiepileptic drugs (carbamazepine, phenytoin, valproate) reduce the frequencyof spontaneous electrographic epileptiform discharges (Ziyatdinova etal. Epilepsy Res 2011).
In contrast, APP/PS1 hemizygotes on aC57BL/6J-congenic background exhibit seizure activity. Specifically, hemizygousmice on the C57BL/6 background (N9B6) exhibit a high incidence of seizures, asdetected by video-EEG. 25% of transgenic mice, 3 to 3.5 months in age, exhibitat least 1 seizure. By 4.5 months of age, seizure incidence increases to 55%.10-15% mortality is reported for transgenic mice on the congenic (N9) C57BL/6background (Minkeviciene et al. J Neurosci. 2009). At 17-18 weeks ofage, hemizygous mice on the congenic C57BL/6J background (N13) exhibitepileptiform discharges as detected by video-EEG. Mortality was 38% (6/16) andsome mutant mice experienced spontaneous seizures during the experiments.Antiepileptic drugs (carbamazepine, phenytoin, valproate) reduce the frequencyof spontaneous electrographic epileptiform discharges (Ziyatdinova etal. Epilepsy Res 2011).
